Bruno Cogliati 

Assistant professor of General and Animal Pathology at the School of Veterinary Medicine and Animal Science, USP, Sao Paulo, Brazil

 

bcogliati@usp.br

 

About:

Dr. Bruno Cogliati graduated in Veterinary Medicine at the University of Sao Paulo (USP) in 2005. He had a Doctorate degree in Comparative and Experimental Pathology from the USP (Fellowship from Sao Paulo State Agency, FAPESP). Dr. Cogliati has done a Postdoc at USP School of Medicine on experimental nonalcoholic fatty liver disease (FAPESP Fellowship). Since 2011, Dr. Cogliati has been assistant professor of General and Animal Pathology at the School of Veterinary Medicine and Animal Science, USP, Sao Paulo, Brazil. He is currently coordinator of the International Affairs Office at the same Institution. He is a member of the Vrije Universiteit Brussel-USP Alliance Research Group and FWO Scientific Research Network. He was awarded with a prestigious Research Productivity Fellow from National Council for Scientific and Technological Development (CNPq)

Dr. Cogliati’s Lab has been studying liver diseases for the last 10 years, with emphasis on acute and chronic liver injuries, hepatocellular carcinoma (HCC) and the role of connexin/pannexin (hemi)channels in comparative and translational liver pathology. His major achievements were related to the implication of connexin 43, 32 and 26 and pannexin-1 in acute liver failure, liver fibrosis/cirrhosis, nonalcoholic steatohepatitis, and HCC. Of interest, we demonstrated that (hemi)channels inhibition by peptides strategy was able to ameliorate liver function and tissue structure. In recent years, we focused on translating these data into humans by looking at the expression and function of those (hemi)channels in cirrhotic and HCC patients 

Recent Publication: 

  • Cooreman A, Van Campenhout R, Ballet S, Annaert P, Van Den Bossche B, Colle I, Cogliati B, Vinken M. (2019) Connexin and Pannexin (Hemi)Channels: Emerging Targets in the Treatment of Liver Disease. Hepatology. 69(3):1317-1323. doi: 10.1002/hep.30306.
  • Crespo Yanguas S, da Silva TC, Pereira IVA, Maes M, Willebrords J, Shestopalov VI, Goes BM, Sayuri Nogueira M, Alves de Castro I, Romualdo GR, Barbisan LF, Gijbels E, Vinken M*, Cogliati B*. (2018) Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model. Arch Toxicol. 92(8):2607-2627. doi: 10.1007/s00204-018-2255-3. *these authors share equal seniorship.
  • Crespo Yanguas S, da Silva TC, Pereira IVA, Willebrords J, Maes M, Sayuri Nogueira M, Alves de Castro I, Leclercq I, Romualdo GR, Barbisan LF, Leybaert L, Cogliati B*, Vinken M*. (2018) TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018; 19(3):817. doi: 10.3390/ijms19030817. *these authors share equal seniorship.
  • Willebrords J, Maes M, Pereira IVA, da Silva TC, Govoni VM, Lopes VV, Crespo Yanguas S, Shestopalov VI, Nogueira MS, de Castro IA, Farhood A, Mannaerts I, van Grunsven L, Akakpo J, Lebofsky M, Jaeschke H, Cogliati B*, Vinken M*. (2018) Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. Biochim Biophys Acta Mol Basis Dis. 1864(3):819-830. doi: 10.1016/j.bbadis.2017.12.013. *these authors share equal seniorship.
  • Tiburcio TC, Willebrords J, da Silva TC, Pereira IV, Nogueira MS, Crespo Yanguas S, Maes M, Silva ED, Dagli ML, de Castro IA, Oliveira CP, Vinken M*, Cogliati B*. (2017) Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis. Clin Exp Pharmacol Physiol. 44(2):197-206. doi: 10.1111/1440-1681.12701. *these authors share equal seniorship.
  • Willebrords J*, Cogliati B*, Pereira IVA, da Silva TC, Crespo Yanguas S, Maes M, Govoni VM, Lima A, Felisbino DA, Decrock E, Nogueira MS, de Castro IA, Leclercq I, Leybaert L, Rodrigues RM, Vinken M. (2017) Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice. Sci Rep. 15;7(1):8268. doi: 10.1038/s41598-017-08583-w. *these authors share equal first authorship.
  • Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B*, Vinken M*. (2017) Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity. Arch Toxicol. 91(5):2245-2261. doi: 10.1007/s00204-016-1885-6. Erratum in: Arch Toxicol. 2017 May;91(5):2263-2264. *these authors share equal seniorship.
  • Crespo Yanguas S, Willebrords J, Johnstone SR, Maes M, Decrock E, De Bock M, Leybaert L, Cogliati B*, Vinken M*. (2017) Pannexin1 as mediator of inflammation and cell death. Biochim Biophys Acta Mol Cell Res. 1864(1):51-61. doi: 10.1016/j.bbamcr.2016.10.006. *these authors share equal seniorship.
  • Cogliati B, Crespo Yanguas S, da Silva TC, Aloia TPA, Nogueira MS, Real-Lima MA, Chaible LM, Sanches DS, Willebrords J, Maes M, Pereira IVA, de Castro IA, Vinken M, Dagli MLZ. (2016) Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice. Toxicol Mech Methods. 26(5):362-370. doi: 10.1080/15376516.2016.1190991.
  • Cogliati B, Da Silva TC, Aloia TP, Chaible LM, Real-Lima MA, Sanches DS, Matsuzaki P, Hernandez-Blazquez FJ, Dagli ML. (2011) Morphological and molecular pathology of CCL4-induced hepatic fibrosis in connexin43-deficient mice. Microsc Res Tech. 74(5):421-9. doi: 10.1002/jemt.20926.